The last thirty years have seen a significant increase in the number of universities, instructors, and students alike, yet institutions of higher education currently face a number of problems and are plagued with uncertainty, pressure, and fear. Their status as ivory towers detached from the social and political environments of contemporary democracies creates an atmosphere of mutual distrust. This then leads to the imposition of regulatory measures incongruent with the workings of universities, which only deepens the prevailing issues. The essays in this publication explore these issues, focus on the self-constituting character of the university (the so-called autopoiesis) and present several detailed case studies.